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REVIEW ARTICLE
Year : 2015  |  Volume : 12  |  Issue : 5  |  Page : 389-405

The antioxidant master glutathione and periodontal health


1 Department of Periodontology, Sarsawati Dental College and Hospital, Lucknow, Uttar Pradesh, India
2 Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
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House Number 1317, Sector 16, Indiranagar, Lucknow - 226 016, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-3327.166169

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Glutathione, considered to be the master antioxidant (AO), is the most-important redox regulator that controls inflammatory processes, and thus damage to the periodontium. Periodontitis patients have reduced total AO capacity in whole saliva, and lower concentrations of reduced glutathione (GSH) in serum and gingival crevicular fluid, and periodontal therapy restores the redox balance. Therapeutic considerations for the adjunctive use of glutathione in management of periodontitis, in limiting the tissue damage associated with oxidative stress, and enhancing wound healing cannot be underestimated, but need to be evaluated further through multi-centered randomized controlled trials.


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