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ORIGINAL ARTICLE
Year : 2016  |  Volume : 13  |  Issue : 4  |  Page : 338-341

Evaluation of salivary nitric oxide level in children with early childhood caries


1 Department of Pedodontics and Preventive Dentistry, Chettinad Dental College and Research Institute, Kelambakkam, India
2 Department of Pedodontics and Preventive Dentistry, Mahatma Gandhi Post Graduate Institute of Dental Sciences, Puducherry, India
3 Department of Pedodontics, Saveetha Dental College and Hospital, Chennai, India
4 Department of Oral Pathology and Microbiology, Thai Moogambigai Dental College and Hospital, Chennai, India
5 Department of Conservative Dentistry and Endodontics, Rajah Muthiah Dental College and Hospital, Chidambaram, India

Correspondence Address:
Dr. A R Senthil Eagappan
Department of Pedodontics and Preventive Dentistry, Chettinad Dental College and Research Institute, Chettinad Health City, Kelambakkam, Kancheepuram - 603 103, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-3327.187882

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Background: Nitric oxide (NO), a highly reactive radical, participates in the nonspecific natural defense mechanism of the oral cavity. The present study was attempted to evaluate the salivary NO levels in 4–5 year-old children with early childhood caries (ECC). The objective of the present study was to assess the salivary NO concentration in children with different caries activity. Materials and Methods: The study included 120 healthy 4–5 year-old children and they were equally divided into three groups based on decayed, missing, filled surfaces (dmfs) score; forty caries-free children (control group), forty children with dmfs 1–5 (ECC group), and forty with dmfs ≥6 (severe ECC group). Saliva collected was measured for NO concentration by Griess reaction method. The obtained data were analyzed by ANOVA and Pearson's correlation coefficient. Results: The mean level of NO in the saliva of the control group was 51.2 ± 8.3457 and that of ECC and severe ECC were 47.1 ± 5.2614 and 33.625 ± 4.6942, respectively. The mean salivary NO concentration was significantly higher in healthy controls when compared to children with ECC and severe ECC. Moreover, a negative correlation (r = −0.6658) was observed between the salivary NO level and the mean dmfs, suggesting that as the salivary NO level decreases, the caries incidence increases. Conclusion: The obtained results support the antimicrobial activity of salivary NO and also suggest that an increase in NO production might contribute to lower the caries occurrence in children.


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