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ORIGINAL ARTICLE
Year : 2018  |  Volume : 15  |  Issue : 1  |  Page : 40-49

Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats


1 Department of Orthodontic, International Campus, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Orthodontic and Dental Research, Research Institute of Dental Sciences Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Life Sciences, Faculty of Science and Technology, Applied Biotechnology Research Group, University of Westminster, London, UK
4 Department of Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Iran

Correspondence Address:
Dr. Sohrab Asefi
No 2, Jashnvareh Street, 2nd Square of Tehranpars, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-3327.223618

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Background: Curcumin is the most active compound in turmeric. It can suppress the nuclear factor kappa-light-chain-enhancer of activated B cells pathway and prevent the osteoclastogenesis procedure. This study aimed to be the first to evaluate the effect of curcumin on the rate of orthodontic tooth movement (OTM). Materials and Methods: Forty rats were used as follows in each group: (1) negative control: Did not receive any appliance or injection; (2) positive control: received 0.03 cc normal saline and appliance; (3) gelatin plus curcumin (G): Received 0.03 cc hydrogel and appliance; and (4) chitosan plus curcumin (Ch): Received 0.03 cc hydrogel and appliance. They were anesthetized and closed nickel-titanium coil springs were installed between the first molars and central incisors unilaterally as the orthodontic appliance. After 21 days, the rats were decapitated, and the distance between the first and second molars was measured by a leaf gauge. Howship's lacunae, blood vessels, osteoclast-like cells, and root resorption lacunae were evaluated in the histological analysis. Data were analyzed by one-way ANOVA, Tukey's test, and t-test (P < 0.05 consider significant). Results: No significant difference was found in OTM between groups delivered orthodontic forces. Curcumin inhibited root and bone resorption, osteoclastic recruitment, and angiogenesis significantly. Conclusion: Curcumin had no significant inhibitory effect on OTM. While it had a significant role on decreasing bone or root resorption (P > 0.05).


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