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Year : 2020  |  Volume : 17  |  Issue : 3  |  Page : 174-178

Association of the mir-499 polymorphisms with oral cavity and oropharyngeal squamous cell carcinoma in an Iranian population

1 Department of Oral Medicine, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran
2 Department of Medical Basic Sciences and Medical Basic Biotechnologhy, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran
3 Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Arash Motaghi
Department of Oral Medicine, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1735-3327.284734

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Background: Oral squamous cell carcinoma (SCC) is the most common oral malignancy. Some evidence indicated that there is a correlation between microRNA single nucleotide polymorphisms and the risk of oral cancer. The aim of the current study was to investigate the association between mir-499 polymorphism with the risk of oral cavity and oropharyngeal SCC in a subset of Iranian Population. Materials and Methods: In this case–control pilot study total of 112 participants including 56 histopathlogically confirmed oral and oropharyngeal SCC patients and 56 age- and sex-matched controls were included The mir-499 rs3746444 T/C polymorphism was detected using polymerase chain reaction-restriction fragment length polymorphism method. The comparisons of the distribution of the allele and genotype frequencies were performed using Chi-square test, and P < 0.05 was considered as statistically significant. Results: The result of the present study indicated that the frequency distribution of mir-499 was not significantly different between cases and controls (P > 0.05). We also did not find any significant association between the risk of the cancer and mir-499 polymorphisms in the recessive (Odds ratio [OR]: 6.60; 95% confidence interval [CI]: 0.77–56.74; P = 0.11) and dominant (OR: 1; 95% CI: 0.37–2.74; P = 1) inheritance models even after adjustment for smoking. Conclusion: The results of the present study indicated that the polymorphisms of mir-499 are not associated with the risk of oral and oropharyngeal SCC in Iranian population. However, further large scale studies are needed to validate our findings.

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