| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 15
| Issue : 6 | Page : 385-390 |
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Comparison of the permeability rate of nanoparticle calcium hydroxide and conventional calcium hydroxide using a fluorescence microscope
Babak Farzaneh1, Sina Azadnia1, Reza Fekrazad2
1 Department of Endodontic, Dental School, AJA University of Medical Sciences, Tehran, Iran
2 Department of Periodontology, Dental Faculty - Laser Research Center in Medical Sciences, AJA University of Medical Sciences; International Network for Photo Medicine and Photo Dynamic Therapy, Universal Scientific Education and Research Network, Tehran, Iran
Correspondence Address:
Dr. Reza Fekrazad
Department of Periodontology, Dental School, AJA University of Medical Sciences, Etemad Zadeh Street, West Fatemi Street, Tehran
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1735-3327.245236
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Background: The permeability feature of conventional calcium hydroxide (CH) and nanoparticle CH (NCH) was compared to show the desired effects of this new material and in case of confirmation of its other properties; CH can be used as a safe alternative.
Materials and Methods: This in vitro was carried out in two phases: First phase: measurement and comparison of the permeability rate of conventional CH and NCH in the dentinal tubules employing a fluorescence microscope were carried out. Second phase: measurement and comparison of the permeability rate of NCH and conventional CH in L929 fibroblast cells using a fluorescence microscope were carried out. Kruskal–Wallis analysis was used for overall comparisons. A series of Mann–Whitney U tests were used for pair-wise comparisons (P < 0.05).
Results: Based on the results of Kruskal–Wallis test, in all three regions of the cervical third, middle third, and apical third of the root, mean values of the percentage difference of the fluorescence and color change in NCH were more than the conventional CH, and the difference was statistically significant (P < 0.001). the percentage of fluorescence color change in drug with the concentration of 1 g/cc was more than the one with the concentration of 0.1 g/cc and the difference was statistically significant (P < 0.001).
Conclusion: The nanoparticle drug compared with the conventional drug has a more penetration depth in all regions of the root of the dentinal tubules.
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