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Year : 2020  |  Volume : 17  |  Issue : 5  |  Page : 354-359

Comparison of the effects of toothpastes containing nanohydroxyapatite and fluoride on white spot lesions in orthodontic patients: A randomized clinical trial

1 Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Dental School Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Dentist, Private Practice, Tehran, Iran
3 Department of Pharmacology and Toxicology, Pharmacy Faculty, Isfahan University of Medical Sciences, Isfahan, Iran
4 Associate Professor of Orthodontics, Department of Orthodontic, Dental School, Semnan University of Medical Sciences, Semnan, Iran
5 Department of Restorative Dentistry, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Correspondence Address:
Dr. Asghar Ebadifar
Shahid Beheshti Dental School, Evin St., Chamran High Way, Tehran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1735-3327.294328

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Background: Studies show that fluoride (F) and nano-hydroxyapatite (nano-HA) would result in remineralization of white spot lesions (WSLs), which are among the most prevalent consequences of fixed orthodontic treatment. The present study evaluates and compares the clinical effects of an Iranian toothpaste containing nano-HA with F-containing one on early enamel lesions. Materials and Methods: In this randomized clinical trial study, 50 patients who had received fixed orthodontic treatment were recruited immediately after debonding. Three photographs, including frontal, lateral right and left views of occlusion, were obtained. Moreover, surfaces with WSLs were recorded using DIAGNOdent. Plaque index of each patient determined using disclosing agents. At first visit, each patient was asked to select one type of toothpaste (nano-HA containing vs. F containing named A or B), randomly and were instructed how to brush their teeth (25 patients in each group). Examination was done at 1, 3, and 6 months' intervals. Finally, photographs were analyzed by Digimizer (V5) software, and the lesion extent was recorded in pixels. SAS 9.4 was used to analyze data and was set at 0.05. Results: According to data, lesion extent showed a significant decrease (P < 0.001). At baseline, the difference between the two groups regarding the lesion extent was 268 pixels while it dropped to 89 pixels after 6 months. DIAGNOdent results showed that at baseline, fluorescence difference was 0.3 while it reached the number of 0.8 after 6 months, indicating the outperformance of nano-HA containing toothpaste. Conclusion: The Iranian nano-HA containing toothpaste performed better than F-containing one in terms of the amount of remineralization and diminishing the lesion extent.

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