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REVIEW ARTICLES
Outcomes of vital pulp therapy in permanent teeth with different medicaments based on review of the literature
Najmeh Akhlaghi, Abbasali Khademi Khademi
September-October 2015, 12(5):406-417
DOI
:10.4103/1735-3327.166187
PMID
:26604953
Vital pulp therapy (VPT) is a biologic and conservative treatment modality to preserve the vitality and function of the coronal or remaining radicular pulp tissue in vital permanent teeth. A search was conducted via the Cochrane database, PubMed, MEDLINE, and Ovid for any articles with the criteria for "pulp-capping," or "pulp-capping materials" and "VPT outcomes" from 1978 to mid 2014. All articles were evaluated and the valid papers were selected. The outcomes of various VPT techniques, including indirect pulp treatment, direct pulp treatment, partial pulpotomy, and complete pulpotomy in vital permanent teeth were extracted. Although various studies have different research approach, most studies noted a favorable treatment outcome. Mineral trioxide aggregate (MTA) appears to be more effective than calcium hydroxide (Ca(OH)
2
) for maintaining long-term pulp vitality after indirect and direct pulp-capping. However, it seems that the success rate for partial pulpotomy and pulpotomy with Ca(OH)
2
is similar to MTA.
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8,102
1,960
ORIGINAL ARTICLES
Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients
Bhavana S Bagalad, KP Mohankumar, GS Madhushankari, Mandana Donoghue, Puneeth Horatti Kuberappa
January-February 2017, 14(1):13-18
DOI
:10.4103/1735-3327.201138
PMID
:28348612
Background:
The prevalence of chronic renal failure is increasing because of increase in chronic debilitating diseases and progressing age of population. These patients experience accumulation of metabolic byproducts and electrolyte imbalance, which has harmful effects on their health. Timely hemodialysis at regular intervals is a life-saving procedure for these patients. Salivary diagnostics is increasingly used as an alternative to the traditional methods. Thus, the aim of the present study was to determine the diagnostic efficacy of saliva in chronic renal failure patients.
Materials and Methods:
This case–control study included 82 individuals, of which 41 were chronic renal failure patients and 41 were age- and sex-matched controls. Blood and saliva were collected and centrifuged. Serum and supernatant saliva were used for biochemical analysis. Serum and salivary urea, creatinine, sodium, potassium, calcium, and phosphorus were evaluated and correlated in chronic renal failure patients using unpaired
t
-test, Pearson's correlation coefficient, diagnostic validity tests, and receiver operative curve.
Results:
When compared to serum; salivary urea, creatinine, sodium, and potassium showed diagnostic accuracy of 93%, 91%, 73%, and 89%, respectively, based on the findings of study.
Conclusion:
It can be concluded that salivary investigation is a dependable, noninvasive, noninfectious, simple, and quick method for screening the mineral and metabolite values of high-risk patients and monitoring the renal failure patients.
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15
2,904
363
REVIEW ARTICLES
Prevalence of malocclusion among Iranian children: A systematic review and meta-analysis
Maryam Akbari, Kamran Bagheri Lankarani, Behnam Honarvar, Reza Tabrizi, Hossein Mirhadi, Mahmood Moosazadeh
September-October 2016, 13(5):387-395
DOI
:10.4103/1735-3327.192269
PMID
:27857763
Background:
The high prevalence of malocclusion is a public health problem in the world and the third priority in oral care. Numerous primary studies have presented reports on the prevalence of malocclusion among Iranian children. In combination, the results of these studies using meta-analysis are highly valuable for health policy-making. Similarly, this study aimed at determining the prevalence of different types of malocclusion among Iranian children.
Materials and Methods:
Using relevant keywords, national and international databases were explored. After narrowing down the search strategy and leaving out the duplicates, the remaining articles were screened based on titles and abstracts. To increase search sensitivity, reference lists of the papers were examined. To identify unpublished articles and documentations, a set of negotiations were done with the people involved and research centers. Finally, the heterogeneity index between the studies was determined using Cochran (Q) and
I
2
tests. According to the results of heterogeneity, the random effects model was used to estimate the prevalence of malocclusion in Iran.
Results:
In total, 25 articles were included in the meta-analysis process. The prevalence of dental malocclusion was estimated in 28,693 Iranian children aged 3-18 years. The total prevalence of Class I, II, and III malocclusion was 54.6% (46.5-62.7), 24.7% (20.8-28.7), and 6.01% (4-7.1), respectively. The prevalence of Class I, II, and III malocclusion was 44.6% (32.9-56.2), 21.5% (18.01-25.1), and 4.5% (3.2-5.9) in boys and 48.8% (36.8-60.8), 21.5% (16.9-25.1), and 5.5% (3.9-7.1) in girls, respectively.
Conclusion:
This study showed a high prevalence of malocclusion among Iranian children. Also, the results indicated that the prevalence is higher in girls.
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15
2,710
300
ORIGINAL ARTICLES
Influence of different luting protocols on shear bond strength of computer aided design/computer aided manufacturing resin nanoceramic material to dentin
Claudio Poggio, Marco Pigozzo, Matteo Ceci, Andrea Scribante, Riccardo Beltrami, Marco Chiesa
March-April 2016, 13(2):91-97
DOI
:10.4103/1735-3327.178193
PMID
:27076822
Background:
The purpose of this study was to evaluate the influence of three different luting protocols on shear bond strength of computer aided design/computer aided manufacturing (CAD/CAM) resin nanoceramic (RNC) material to dentin.
Materials and Methods:
In this
in vitro
study, 30 disks were milled from RNC blocks (Lava Ultimate/3M ESPE) with CAD/CAM technology. The disks were subsequently cemented to the exposed dentin of 30 recently extracted bovine permanent mandibular incisors. The specimens were randomly assigned into 3 groups of 10 teeth each. In Group 1, disks were cemented using a total-etch protocol (Scotchbond™ Universal Etchant phosphoric acid + Scotchbond Universal Adhesive + RelyX
™
Ultimate conventional resin cement); in Group 2, disks were cemented using a self-etch protocol (Scotchbond Universal Adhesive + RelyX
™
Ultimate conventional resin cement); in Group 3, disks were cemented using a self-adhesive protocol (RelyX
™
Unicem 2 Automix self-adhesive resin cement). All cemented specimens were placed in a universal testing machine (Instron Universal Testing Machine 3343) and submitted to a shear bond strength test to check the strength of adhesion between the two substrates, dentin, and RNC disks. Specimens were stressed at a crosshead speed of 1 mm/min. Data were analyzed with analysis of variance and
post-hoc
Tukey's test at a level of significance of 0.05.
Results:
Post-hoc
Tukey testing showed that the highest shear strength values (
P
< 0.001) were reported in Group 2. The lowest data (
P
< 0.001) were recorded in Group 3.
Conclusion:
Within the limitations of this
in vitro
study, conventional resin cements (coupled with etch and rinse or self-etch adhesives) showed better shear strength values compared to self-adhesive resin cements. Furthermore, conventional resin cements used together with a self-etch adhesive reported the highest values of adhesion.
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495
REVIEW ARTICLE
Cyclosporine A: Novel concepts in its role in drug-induced gingival overgrowth
Deepa Ponnaiyan, Visakan Jegadeesan
November-December 2015, 12(6):499-506
DOI
:10.4103/1735-3327.170546
PMID
:26759584
Cyclosporine is a selective immunosuppressant that has a variety of applications in medical practice. Like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. This review considers the pharmacokinetics, pharmacodynamics, and unwanted effects of cyclosporine, in particular the action of the drug on the gingival tissues. In addition, elucidates the current concepts in mechanisms of cyclosporine-induced gingival overgrowth. Clinical and cell culture studies suggest that the mechanism of gingival overgrowth is a result of the interaction between the drug and its metabolites with susceptible gingival fibroblasts. Plaque-induced gingival inflammation appears to enhance this interaction. However, understanding of the pathogenesis of gingival overgrowth is incomplete at best. Hence, it would be pertinent to identify and explore possible risk factors relating to both prevalence and severity of drug-induced gingival overgrowth. Newer molecular approaches are needed to clearly establish the pathogenesis of gingival overgrowth and to provide novel information for the design of future preventive and therapeutic modalities.
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843
ORIGINAL ARTICLES
The use of platelet-rich fibrin (PRF) and PRF-mixed particulated autogenous bone graft in the treatment of bone defects: An experimental and histomorphometrical study
Nesligül Niyaz Kökdere, Timuçin Baykul, Yavuz Findik
September-October 2015, 12(5):418-424
DOI
:10.4103/1735-3327.166188
PMID
:26604954
Background:
Various materials and techniques have been developed to facilitate bone healing process and reduce its healing period. In recent studies, it is pointed out that, platelet-rich fibrin (PRF) which is derived autogenously from the own blood of the individuals, increase regeneration and accelerate the healing of the wound, due to the consisting various growing factors. The aim of the experimental study is to evaluate the efficiency of PRF and PRF/autogenous graft combination on bone healing in different time intervals.
Materials and Methods:
A total of 24 skeletally mature New Zealand rabbits were used. Animals were divided randomly into two groups. Two bone defects with a diameter 3, 3 mm were created on the right and left tibia in all group animals. Only particulate autogeneous bone graft, only PRF, combination of PRF and autogeneous bone graft and empty bone cavity, were performed to all animals. The animals in the first experimental group were sacrificed after 30 days. The animals in the second experimental group were sacrificed after 60 days from the operation. Histomorphometrical and statistical analysis was performed. The data were analyzed using Tukey test (
P
< 0.05 for osteoblast number,
P
< 0.01 for osteoclast and new bone area values).
Results:
Histomorphometrical analyzes showed that either PRF used alone or used in conjuction with autogenous bone graft, PRF accelerated the healing of the bone defects. There were statistically significant differences in osteoblast, osteoblast and new bone area values in PRF alone and autogenous graft with PRF than the other groups.
Conclusion:
Our preliminary result demonstrated that PRF increase new bone formation and has a positive effect on early bone healing.
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107
Assessment of oral health-related quality of life in 9-15 year old children with visual impairment in Uttarakhand, India
Aditi Singh, Preeti Dhawan, Vivek Gaurav, Pradeep Rastogi, Shilpi Singh
January-February 2017, 14(1):43-49
DOI
:10.4103/1735-3327.201132
PMID
:28348617
Background:
To assess the prevalence of dental diseases among 9–15-year-old visually impaired children and find out its impact on their daily activities using the Child-Oral Impact on Daily Performance (C-OIDP) questionnaire in districts of Uttarakhand, India.
Materials and Methods:
A total of 423 visually impaired institutionalized children between the age group of 9–15 years were included in the study. Stratified random sampling technique was used to obtain the study population. Dental caries was recorded using dmft for primary dentition and DMFT for permanent dentition, traumatic dental injuries were assessed using traumatic dental injury index, and dentofacial anomalies were recorded using Angle's classification of malocclusion. The Hindi braille version of C-OIDP questionnaire was used to gather information regarding oral health-related quality of life (OHRQoL).
Results:
There was a high dental caries prevalence of 57.7% in visually impaired children. The prevalence of traumatic dental injuries was 50.6%. Crowding (61.5%) was the most commonly seen dentofacial anomaly and the most commonly perceived oral health problem was toothache. There was less favorable OHRQoL in males as compared to females.
Conclusion:
There was a high prevalence of dental diseases in this group and higher C-OIDP scores suggestive of unfavorable OHRQoL.
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302
Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls
Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Mehrnoosh Moudi
January-February 2018, 15(1):71-79
DOI
:10.4103/1735-3327.223614
Background:
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has important roles in the periodontal diseases. The IL10-1082, -819, and -592 polymorphisms in the promoter region of IL-10 gene have been associated with various IL-10 expressions. The aim of this study was to investigate the association between these gene polymorphisms with chronic periodontitis in a sample of Iranian populations from Southeast of Iran.
Materials and Methods:
IL-10 single nucleotide polymorphisms were analyzed in 210 patients with chronic periodontitis (CP) and 100 individuals without CP by polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis of data was performed using the Chi-square test. The risk associated with single alleles, genotypes, and haplotypes were calculated by performing a multiple logistic regression analysis to estimate the odds ratio (OR) and 95% confidence interval (CI).
P
< 0.05 for statistical significance.
Results:
The prevalences of AG and GG genotypes of IL10-1082 were significantly different between CP and control groups in comparison to AA genotype (OR = 2.671; CI = 1.482–4.815;
P
= 0.001 for AG vs. AA, OR = 4.151; CI = 2.128–8.097;
P
< 0.001 for GG vs. AA). In addition, subjects with at least one IL10-1082-G allele were significantly had an increased risk for CP (OR = 2.157; CI = 1.531–3.038;
P
< 0.001). The distribution of the IL10-819 and IL10-592 genotypes was not different between CP and control subjects (
P
= 0.109 and
P
= 0.139, respectively). The combination of different genotypes showed that GCC haplotype was significantly different between groups (OR = 4.379; CI = 1.077–17.807;
P
= 0.039).
Conclusion:
The results demonstrated that IL10-1082 polymorphism was a putative risk factor for chronic periodontitis and associated with increased susceptibility to CP.
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222
REVIEW ARTICLES
Scaffolds in regenerative endodontics: A review
Kinjal M Gathani, Srinidhi Surya Raghavendra
September-October 2016, 13(5):379-386
DOI
:10.4103/1735-3327.192266
PMID
:27857762
Root canal therapy has enabled us to save numerous teeth over the years. The most desired outcome of endodontic treatment would be when diseased or nonvital pulp is replaced with healthy pulp tissue that would revitalize the teeth through regenerative endodontics. 'A search was conducted using the Pubmed and MEDLINE databases for articles with the criteria 'Platelet rich plasma', 'Platelet rich fibrin', 'Stem cells', 'Natural and artificial scaffolds' from 1982-2015'. Tissues are organized as three-dimensional structures, and appropriate scaffolding is necessary to provide a spatially correct position of cell location and regulate differentiation, proliferation, or metabolism of the stem cells. Extracellular matrix molecules control the differentiation of stem cells, and an appropriate scaffold might selectively bind and localize cells, contain growth factors, and undergo biodegradation over time. Different scaffolds facilitate the regeneration of different tissues. To ensure a successful regenerative procedure, it is essential to have a thorough and precise knowledge about the suitable scaffold for the required tissue. This article gives a review on the different scaffolds providing an insight into the new developmental approaches on the horizon.
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3,620
745
ORIGINAL ARTICLES
Comparison of prevalence of periodontal disease in women with polycystic ovary syndrome and healthy controls
Mohammad Ehsan Rahiminejad, Amirhossein Moaddab, Hassan Zaryoun, Soghra Rabiee, Arta Moaddab, Amin Khodadoustan Khodadoustan
November-December 2015, 12(6):507-512
DOI
:10.4103/1735-3327.170547
PMID
:26759585
Background:
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, affecting 4-18% of them. Previous studies also showed that periodontal diseases are associated with different components of the metabolic syndrome. The aim of this study is to determine the association between PCOS and periodontal diseases.
Materials and Methods:
A total of 196 women (98 with PCOS and 98 healthy controls) were enrolled. PCOS diagnosis was confirmed by history, clinical signs, physical examination, laboratory parameters, and ultrasound studies. Both cases and controls were examined by the same periodontist. Periodontal parameters including bleeding on probing (BOP), probing depth, clinical attachment loss (CAL), plaque index, and tooth loss were investigated in all participants. Pregnant women, smokers, individuals with a history of malignancy or osteoporosis, and those taking prophylactic antibiotics for dental procedures or receiving periodontal treatment during the 6-month period before examination were excluded. Data were analyzed using
t
-test, Chi-square test, and linear regression. Statistical significance was set at
P
< 0.05.
Results:
CAL and sites with BOP were significantly higher in women with PCOS (
P
< 0.05). However, no significant difference was observed in the tooth loss rate between PCOS and non-PCOS participants (
P
= 0.384).
Conclusion:
The prevalence of periodontal disease seems to be higher in women with PCOS. This may be related to the role of chronic systemic inflammation in the pathophysiology of both PCOS and periodontal diseases.
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10
2,405
348
A comparative evaluation of remineralizing ability of bioactive glass and amorphous calcium phosphate casein phosphopeptide on early enamel lesion
Udaya Kumar Palaniswamy, Neha Prashar, Mamta Kaushik, Surender Ram Lakkam, Shikha Arya, Swetha Pebbeti
July-August 2016, 13(4):297-302
DOI
:10.4103/1735-3327.187872
PMID
:27605985
Background:
This study was done to evaluate remineralizing potential of bioactive glasses (BAGs) and amorphous calcium phosphate-casein phosphopeptide (ACP-CPP) on early enamel lesion.
Materials and Methods:
Twenty freshly extracted mandibular premolars were sectioned sagittally. The buccal half was impregnated in acrylic resin blocks and treated with 37% phosphoric acid in liquid form, to demineralize enamel surface to simulate early enamel lesion. The samples were divided into two groups. The samples in Group I were treated with ACP-CPP (GC Tooth Mousse) and in Group II with BAG (Sensodyne Repair and Protect) and stored in saliva to prevent dehydration. The samples were tested for microhardness. The data obtained was analyzed using ANOVA
post hoc
multiple comparison and independent sample
t-
test and presented as a mean and standard deviation.
Results:
All the samples showed a decrease in the microhardness after demineralization. After application of remineralizing agents, Group II showed a highly significant increase in the microhardness (
P
< 0.05) after 10 days, while Group I showed a significant increase in microhardness after 15 days (
P
< 0.05).
Conclusion:
Both the remineralizing agents tested in this study can be considered effective in repair and prevention of demineralization. BAG showed better results initially, but eventually both have similar remineralizing potential.
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10
3,143
494
Exploring the missing link - Empathy among dental students: An institutional cross-sectional survey
Vikram Pal Aggarwal, Robin Garg, Nikita Goyal, Puneet Kaur, Sakshi Singhal, Nancy Singla, Deeksha Gijwani, Aditi Sharma
September-October 2016, 13(5):419-423
DOI
:10.4103/1735-3327.192279
PMID
:27857767
Background:
Empathy plays an important role in healthy dentist and patient relationship. Hence, the aim of the study is to (a) to measure the self-reported empathy levels among dental undergraduate and postgraduate students. (b) To review the trend of changes in empathy level with experience, age, and gender among dental undergraduate and postgraduate students.
Materials and Methods:
This cross-sectional, questionnaire-based study was carried out in two private dental institutions situated in Sri Ganganagar, India, with a sample size of 978. Data were obtained from the 1
st
to final year (BDS), interns, and postgraduate students from January to March 2015. An empathy level of students was assessed by the Jefferson Scale of Physician Empathy - Health Profession Students Version Questionnaire. An exploratory factor analysis using Kaiser's criteria was undertaken to appraise the construct validity and dimensionality. Based on the results of the factor analysis, three factors were selected; labeled as "perspective taking," "compassionate care," and "standing in patient's shoes."
Results:
The majority of the students was female in a equivalent ratio of 1338:618. There were significant differences in empathy scores by gender and age (
P
< 0.01). The lowest and highest mean empathy scores were found in postgraduate (mean = 108.77, standard deviation [SD] =9.12) and 1
st
year (mean = 117.23, SD = 14.19) dental students, respectively.
Conclusion:
Dental educators should consider the likely decline in empathy among students as early as possible and adopt communication teaching strategies to promote the development of empathy and reduce the risk of further decline.
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1,985
187
REVIEW ARTICLES
The antioxidant master glutathione and periodontal health
Vivek Kumar Bains, Rhythm Bains
September-October 2015, 12(5):389-405
DOI
:10.4103/1735-3327.166169
PMID
:26604952
Glutathione, considered to be the master antioxidant (AO), is the most-important redox regulator that controls inflammatory processes, and thus damage to the periodontium. Periodontitis patients have reduced total AO capacity in whole saliva, and lower concentrations of reduced glutathione (GSH) in serum and gingival crevicular fluid, and periodontal therapy restores the redox balance. Therapeutic considerations for the adjunctive use of glutathione in management of periodontitis, in limiting the tissue damage associated with oxidative stress, and enhancing wound healing cannot be underestimated, but need to be evaluated further through multi-centered randomized controlled trials.
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3,953
572
ORIGINAL ARTICLES
Accuracy of different impression materials in parallel and nonparallel implants
Mahroo Vojdani, Kianoosh Torabi, Elham Ansarifard
July-August 2015, 12(4):315-322
DOI
:10.4103/1735-3327.161429
PMID
:26288620
Background:
A precise impression is mandatory to obtain passive fit in implant-supported prostheses. The aim of this study was to compare the accuracy of three impression materials in both parallel and nonparallel implant positions.
Materials and Methods:
In this experimental study, two partial dentate maxillary acrylic models with four implant analogues in canines and lateral incisors areas were used. One model was simulating the parallel condition and the other nonparallel one, in which implants were tilted 30° bucally and 20° in either mesial or distal directions. Thirty stone casts were made from each model using polyether (Impregum), additional silicone (Monopren) and vinyl siloxanether (Identium), with open tray technique. The distortion values in three-dimensions (X, Y and Z-axis) were measured by coordinate measuring machine. Two-way analysis of variance (ANOVA), one-way ANOVA and Tukey tests were used for data analysis (α = 0.05).
Results:
Under parallel condition, all the materials showed comparable, accurate casts (
P
= 0.74). In the presence of angulated implants, while Monopren showed more accurate results compared to Impregum (
P
= 0.01), Identium yielded almost similar results to those produced by Impregum (
P
= 0.27) and Monopren (
P
= 0.26).
Conclusion:
Within the limitations of this study, in parallel conditions, the type of impression material cannot affect the accuracy of the implant impressions; however, in nonparallel conditions, polyvinyl siloxane is shown to be a better choice, followed by vinyl siloxanether and polyether respectively.
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633
Effects of three surface conditioning techniques on repair bond strength of nanohybrid and nanofilled composites
Negin Nassoohi, Haleh Kazemi, Morad Sadaghiani, Mona Mansouri, Vahid Rakhshan
November-December 2015, 12(6):554-561
DOI
:10.4103/1735-3327.170575
PMID
:26759592
Background:
Repair bond strength of different composite resins has been assessed in few studies. In addition, reports on the efficacy of surface treatments are debated. Therefore, this
in
vitro
study was conducted to evaluate the effect of three surface treatments on two nanocomposites versus a microhybrid composite.
Materials and Methods:
In this experimental study, 135 composite blocks (45 specimens per composite) of microhybrid (Filtek Supreme Z250, 3M ESPE, USA), nanohybrid (Filtek Supreme XT, 3M ESPE), and nanofilled (Filtek Supreme Z350, 3M ESPE) were thermocycled (5000 rounds) and then surface roughened (except in a control group of 9 specimens of three composite types). Each composite type was divided into three subgroups of surface treatments: (1) Bur abrading and phosphoric acid (PA) etching, (2) sandblasting and PA etching, and (3) hydrofluoric etching and silane application (
n
= 15 × 9, complying with ISO TR11405). Composite blocks were repaired with the same composite type but of a different color. Microtensile bond strength and modes of failure were analyzed statistically using two-way analyses of variance, Tukey and Chi-square tests (α = 0.05).
Results:
There were significant differences between three composite resins (
P
< 0.0001) and treatment techniques (
P
< 0.0001). Their interaction was nonsignificant (
P
= 0.228). The difference between nanofilled and nanohybrid was not significant. However, the microhybrid composite showed a significantly higher bond strength (Tukey
P
< 0.05). Sandblasting was significantly superior to the other two methods, which were not different from each other.
Conclusion:
Within the limitations of this
in vitro
study, it seems that microhybrid composite might have higher repair strengths than two evaluated nanocomposites. Among the assessed preparation techniques, sandblasting followed by PA etching might produce the highest bond strength.
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9
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323
Microbiological analysis after complete or partial removal of carious dentin using two different techniques in primary teeth: A randomized clinical trial
Deepak Kumar Singhal, Shashidhar Acharya, Arun Singh Thakur
January-February 2016, 13(1):30-37
DOI
:10.4103/1735-3327.174695
PMID
:26962313
Background:
The management of deep carious lesions can be done by various techniques but residual caries dilemma still persists and bacterial reduction in cavities treated by either partial or complete caries removal techniques is debatable. So the objective of the present randomized clinical trial was to compare microbial counts in cavities submitted to complete caries removal and partial caries removal using either hand instruments or burs before and after 3 weeks of restoration.
Materials and Methods:
Primary molars with acute carious lesions in inner half of dentine and vital pulp were randomly divided into three groups of 14 each: Group A: Partial caries removal using hand instruments atraumatic restorative treatment (ART) only; Group B: Partial caries removal using bur; Group C: Complete caries removal using bur and caries detector dye. Dentine sample obtained after caries removal and 3 weeks after restoration, were subjected to microbial culture and counting (colony-forming units [CFU]/mg of dentine) for total viable bacterial count,
Streptococcus
spp., mutans streptococci,
Lactobacillus
spp.
Results:
Three techniques of caries removal showed significant (
P
< 0.05) reduction in all microorganisms studied after 3 weeks of evaluation, but there was no statistically significant difference in percentage reduction of microbial count among three groups.
Conclusion:
Results suggest the use of partial caries removal in a single session as compared to complete caries removal as a part of treatment of deep lesions in deciduous teeth in order to reduce the risk of pulp exposure. Partial caries removal using ART can be preferred for community settings as public health procedure for caries management.
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9
3,468
635
The effect of two remineralizing agents and natural saliva on bleached enamel hardness
Haleh Heshmat, Maryam Hoorizad Ganjkar, Yasaman Miri, Mohamad Javad Kharrazi Fard
January-February 2016, 13(1):52-57
DOI
:10.4103/1735-3327.174713
PMID
:26962316
Background:
In order to compensate the adverse consequences of bleaching agents, the use of fluoride-containing remineralizing agents has been suggested by many researchers. The aim of this study was to compare the effect of applying two remineralizing materials on bleached enamel hardness and in comparison to natural saliva.
Materials and Methods:
In this experimental study, 30 enamel samples of sound human permanent molars were prepared for this study. Microhardness (MH) of all specimens was measured and 35% hydrogen peroxide was applied 3 times to the specimens. After completion of the bleaching process, MH of samples was measured and then enamel specimens were divided into three groups each of 10, specimens of groups 1 and 2 were subjected to daily application of hydroxyl apatite (Remin Pro) and casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACPF) (MI Paste Plus) pastes, respectively, for 15 days. In group 3, the specimens were stored in the operators' natural saliva at room temperature in this period of time. Final MH of all groups was measured. The data were analyzed using repeated measures ANOVA (α = 0.05).
Results:
The hardness significantly decreased in all groups following bleaching. Application of either Remin Pro, CPP-ACPF or natural saliva increased the hardness significantly. The hardness of the three test groups after 15 days were statistically similar to each other.
Conclusion:
The hardness of enamel increases eventually after exposure to either MI Paste Plus, Remin Pro or natural saliva.
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3,182
865
CASE REPORTS
Management of external perforating root resorption by intentional replantation followed by Biodentine restoration
Preeti Jain Pruthi, Umesh Dharmani, Ruchika Roongta, Sangeeta Talwar
September-October 2015, 12(5):488-493
DOI
:10.4103/1735-3327.166235
PMID
:26604965
Resorption of tooth structures can occur as a result of physiological, pathological, and idiopathic factors. Early diagnosis and appropriate treatment can prevent its serious complications. This case report presents surgical endodontic management of a trauma-induced perforating external root resorption, which was diagnosed with the help of cone beam computed tomography. Following root canal treatment, intentional replantation of the tooth was performed so as to expose the opening of the resorption defect to allow for complete debridement and closure. Eighteen months follow-up showed arrest of root resorption, and progressive healing of the defect.
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8
2,765
430
ORIGINAL ARTICLES
The effect of low-level helium-neon laser on oral wound healing
Farimah Sardari, Farzaneh Ahrari
January-February 2016, 13(1):24-29
DOI
:10.4103/1735-3327.174693
PMID
:26962312
Background:
The effectiveness of low power lasers on incisional wound healing, because of conflicting results of previous studies, is uncertain. Therefore, the aim of this study was to evaluate the effects of low-level helium-neon (He-Ne) laser irradiation on wound healing in rat's oral mucosa.
Materials and Methods:
Sixty-four standardized incisions were carried out on the buccal mucosa of 32 male Wistar divided into four groups of eight animals each. Each rat received two incisions on the opposite sides of the buccal mucosa by a steel scalpel. On the right side (test side), a He-Ne laser (632 nm) was employed on the incision for 40 s. Laser radiation was used just in 1
st
day, 1
st
and 2
nd
day, 1
st
and 3
rd
day, and continuous 3 days in groups of A, B, C, and D of rats, respectively. The left side (control side) did not receive any laser. Histological processing and hematoxylin and eosin staining were done on tissue samples after 5 days. Wilcoxon and Kruskal-Wallis tests were used for statistical analysis.
Results:
Histological analysis showed that the tissue healing after continuous 3 days on the laser irradiated side was better than the control side, but there was no difference between the two sides in each groups (
P
> 0.05).
Conclusion:
This study showed that He-Ne laser had no beneficial effects on incisional oral wound healing particularly in 5 days after laser therapy. Future research in the field of laser effects on oral wound healing in human is recommended.
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8
2,668
324
Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study
Kumar Chandan Srivastava, Ravi David Austin, Deepti Shrivastava
March-April 2016, 13(2):181-187
DOI
:10.4103/1735-3327.178210
PMID
:27076834
Background:
Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls.
Materials and Methods:
A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean standard deviation. The statistical comparisons between the study groups were performed by independent Student's unpaired
t
-test and one-way analysis of variance.
Post-hoc
analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05).
Results:
Significant reduction in lipid peroxidation (
P
< 0.001) SOD and CAT (
P
< 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples.
Conclusion:
Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker.
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8
2,158
297
Effect of local administration of platelet-derived growth factor B on functional recovery of peripheral nerve regeneration: A sciatic nerve transection model
Atefeh Golzadeh, Rahim Mohammadi
May-June 2016, 13(3):225-232
DOI
:10.4103/1735-3327.182181
PMID
:27274342
Background:
Effects of platelet-derived growth factor B (PDGF-B) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model.
Materials and Methods:
Forty-five male, white Wistar rats were divided into three experimental groups (
n
= 15), randomly: Normal control group (NC), silicon group (SIL), and PDGF-B treated group (SIL/PDGF). In NC group, left sciatic nerve was exposed through a gluteal muscle incision and after homeostasis muscle was sutured. In the SIL group, the left sciatic nerve was exposed in the same way and transected proximal to tibio-peroneal bifurcation leaving a 10-mm gap. Proximal and distal stumps were each inserted into a silicone conduit and filled with 10 μL phosphate buffered solution. In SIL/PDGF group, the silicon conduit was filled with 10 μL PDGF-B (0.5 ng/mL). Each group was subdivided into three subgroups of five and were studied in 4, 8, 12 weeks after surgery.
Results:
Behavioral testing, sciatic nerve functional study, gastrocnemius muscle mass, and histomorphometric studies showed earlier regeneration of axons in SIL/PDGF than in SIL group (
P
< 0.05).
Conclusion:
Local administration of PDGF-B combined with silicon grafting could accelerate functional recovery and may have clinical implications for the surgical management of patients after facial nerve transection.
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8
2,638
273
Systemic effects of fluoxetine on the amount of tooth movement, root resorption, and alveolar bone remodeling during orthodontic force application in rat
Mehdi Rafiei, Soosan Sadeghian, Nakisa Torabinia, Valiollah Hajhashemi
September-October 2015, 12(5):482-487
DOI
:10.4103/1735-3327.166232
PMID
:26604964
Background:
Antidepressant drugs such as fluoxetine are of the most commonly used drugs among the public. These drugs may impact the regulation of bone cell functioning, and thus affect orthodontic tooth movement. The aim of this study was to determine the effect of fluoxetine on tooth movements during orthodontic treatment in rats.
Materials and Methods:
In this study, 30 male rats were randomly assigned into two groups and injected with fluoxetine 10 mg/kg (experimental group) and normal saline (control group) for a period of 1-month intraperitoneally 5 times/week. Then, the rats were anesthetized and a nickel-titanium closed-coil spring was placed between the left maxillary first molar and left maxillary central incisors of all samples, and then fluoxetine (experimental group) and normal saline (control group) were injected for another 3 weeks by the same method. After measuring tooth movements, rats were sacrificed, and histomorphometric analyses were conducted and the obtained data were statistically analyzed using independent
t
-test and the significance was set at 0.05.
Results:
Following the fluoxetine injection, the mean amount of tooth movements in the experimental group was reduced compared to the control group, which was not statistically significant (
P
= 0.14). There was no significant difference between the two groups regarding bone apposition rate (
P
= 0.83), external root resorption rate (
P
= 0.1), and mean number of root resorption lacunae (
P
= 0.16).
Conclusion:
Within the limitations of this study, systemic use of fluoxetine may cause insignificant reduction of tooth movement rate in rats; however, this subject needs more evaluations.
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7
2,336
297
Expression of Bcl-2 and epithelial growth factor receptor proteins in keratocystic odontogenic tumor in comparison with dentigerous cyst and ameloblastoma
Seyed Mohammad Razavi, Nakisa Torabinia, Mohammad Reza Mohajeri, Shahriyar Shahriyary, Shirin Ghalegolab, Samin Nouri
July-August 2015, 12(4):342-347
DOI
:10.4103/1735-3327.161451
PMID
:26288624
Background:
Keratocystic odontogenic tumor (KCOT) is a developmental odontogenic cyst on which various investigations have been focused due to its biological activities, high tendency to recur and different growth mechanisms in comparison with other cystic lesions. Previous studies have shown different biological and proliferative activities for the lining epithelium of KCOT. The aim of this study was immunohistochemical evaluation of Bcl-2 and epidermal growth factor receptor (EGFR) expression in KCOT compared with dentigerous cyst and ameloblastoma.
Materials and Methods:
Formalin-fixed and paraffin-embedded tissue sections of 16 cases of KCOT, 16 cases of dentigerous cyst and 16 cases of ameloblastoma were immunohistochemically analyzed to determine Bcl-2 and EGFR proteins' expression. Biotin-Stereotavidin method was used. It was observed by two oral pathologists separately, and the data were analyzed by Mann-Whitney and Kruskul-Wallis.
P
< 0.05 was considered as significant.
Results:
Regardless of staining intensity, all cases of ameloblastoma and KCOT except dentigerous cases were positively stained for Bcl-2. Expression of Bcl-2 was higher in the peripheral layer of ameloblastoma and basal layer of KCOT. Furthermore, all cases of ameloblastoma and dentigerous cysts except KCOT samples were positively stained for EGFR. Expression of EGFR was higher in the peripheral layer of ameloblastoma and basal layer of dentigerous cysts.
Conclusion:
According to the expression of - Bcl-2 in ameloblastoma and KCOT, and no expression of EGFR in KCOT, it can be concluded that the biological activity and growth mechanisms of KCOT are different compared with other cystic lesions. However, the aggressive potential of KCOT is not as severe as that of a neoplasm such as ameloblastoma.
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7
2,282
362
Analysis of lipid profile in cancer patients, smokers, and nonsmokers
A Vikramsimha Reddy, Lakshmi Keerthana Killampalli, A Ravi Prakash, Sushma Naag, G Sreenath, Sunil Kumar Biraggari
November-December 2016, 13(6):494-499
DOI
:10.4103/1735-3327.197036
PMID
:28182070
Background:
Lipids play an important role in maintaining the cell membrane integrity. Lipid profile is a panel of blood tests that serve as an initial medical screening for abnormalities in lipids and approximate risk for cancer, cardiovascular diseases, pancreatitis, etc., The present study evaluates the alterations in lipid profile in cancer patients, smokers, and nonsmokers and aims to achieve a correlation between them.
Materials and Methods:
The study is an
in vitro
type of cross-sectional study with 25 oral cancer patients, 25 chronic smokers (habit persisting for 15 years or more), and 15 nonsmokers as control group. Blood samples had been collected, and triglycerides (TGs), total cholesterol (TC), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) were analyzed using a lipid profile kit and an autoanalyzer. The results were analyzed using the unpaired
t
-test and ANOVA test (
P
< 0.05).
Results:
There was a significant increase in TC, TG, LDL, and VLDL and decrease in HDL in the smokers group when compared to the controls (
P
< 0.05). A significant increase in LDL, but a decrease in values of HDL, VLDL, TG, and TC was observed in the cancer patients group when compared to the controls (
P
< 0.05).
Conclusion:
There is an inverse relationship between serum lipid profile in smokers and cancer patients. The decrease in lipid profile in cancer patients might be due to their increased utilization of lipids by neoplastic cells in membrane biogenesis. Therefore, a decrease in lipid profile in smokers can be assumed that they might be more prone to develop cancerous conditions.
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7
2,164
226
Assessment of slice thickness effect on visibility of inferior alveolar canal in cone beam computed tomography images
Daryoush Goodarzi Pour, Banafsheh Arzi, Ahmad Reza Shamshiri
November-December 2016, 13(6):527-531
DOI
:10.4103/1735-3327.197041
PMID
:28182059
Objective:
The aim of this study is to evaluate the effect of slice thickness on the visibility of inferior alveolar canal (IAC) in cone-beam computed tomography (CBCT) images.
Materials and Methods:
CBCT images of thirty patients (15 male and 15 female) with an age range between 40–50 years old were used. Cross-sectional images were obtained with 0.5, 1, and 2 mm slice thickness and 2 mm interval. Two oral radiologists with at least 5 years' of experience observed all of the 90 images and rated the images based on the visibility of IAC in a 4-score classification (highly visible, visible, nearly visible, nearly invisible). Friedman test was used for the comparison of visibility of IAC in different slice thicknesses. To do the above test, the average of the scores of two examiners was calculated. A
P.
value below 0.05 was considered significant.
Results:
Visibility of IAC in different slice thicknesses of both raters showed no significant difference (
P
= 0.20).
Conclusion:
Within the limitations of this study the slice thickness has no effect on visibility of IAC in cross-sectional images. Future studies on other multiplanar images are recommended.
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7
1,734
159
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Online since 26
th
February, 2015